Long-course preoperative chemoradiation vs. 5 x 5\u2009Gy and consolidation chemotherapy for clinical T4 and fixed clinical T3 rectal cancer: Long-term results of the randomized Polish II study.

Abstract

BACKGROUND\nThis trial evaluated whether preoperative short-course radiotherapy and consolidation chemotherapy (CCT) were superior to chemoradiation in rectal cancers with clinical (c)T4 or fixed cT3. Previously, we reported early results showing no differences in the radical surgery rate (primary end-point). In the short-course/CCT group, we observed lower acute toxicity of preoperative treatment and better overall survival (OS). We updated results to determine whether the benefit in OS was sustained and to evaluate late complications.\n\n\nPATIENTS AND METHODS\nPatients with cT4 or fixed cT3 rectal cancer were randomized either to preoperative 5 × 5\u2009Gy and three cycles of FOLFOX4 or to chemoradiation (50.4\u2009Gy with bolus 5-Fu, leucovorin and oxaliplatin).\n\n\nRESULTS\n515 patients were eligible for analysis, 261 in the short-course/CCT group and 254 in the chemoradiation group. The median follow-up was 7.0 years. The difference in OS was insignificant, HR\u2009=\u20090.90 (95% confidence interval [CI] 0.70-1.15), P = 0.38. However, the difference in early OS favouring short-course/CCT previously reported was observed again, being 9% at 3 years (95% CI 0.5%-17%). This difference disappeared later; at 8 years OS was 49% in both groups. There was no difference in disease-free survival, HR\u2009=\u20090.95 (95% CI 0.75-1.19), P = 0.65, at 8 years 43% vs. 41% in the short-course/CCT group vs. the chemoradiation group, respectively. The corresponding values for cumulative incidences of local failure and distant metastases did not differ and were HR\u2009=\u20091.08, 95% CI 0.70-1.23, P = 0.60, 35% vs. 32% and HR\u2009=\u20091.10, 95% CI 0.68-1.23, P = 0.54, 36% vs. 34%, respectively. The rate of late complications was similar (P = 0.66), grade 3+ being 11% vs. 9% in the short-course/CCT group vs. the chemoradiation group, respectively.\n\n\nCONCLUSION\nThe superiority of preoperative short-course/CCT over chemoradiation was not demonstrated.\n\n\nCLINICAL TRIAL NUMBER\nThe trial is registered as ClinicalTrials.gov number NCT00833131.