Partial versus radical nephrectomy: 10- year long-term survival among patients with Wilms tumour

Abstract

Abstract Background Wilms tumor (WT) is a rare kidney cancer, but it is the most common malignant tumor of the kidneys of children. Although radical nephroectomy has been viewed as the gold standard surgery in Wilms tumor management for many years, partial nephrectomy has gained a lot of attention recently. So we conducted this study to compare the long term overall survival between those two different surgical techniques. Methods Using SEER database, we extracted the data of 636 patients with WT from 2000 to 2006. There were 55 (8.6%) patients underwent partial nephrectomy, while 581 (91.4%) of them underwent radical nephrectomy. Patients’ demographics were assessed. Results Our study showed that there is NO significant difference in Long-Term overall survival between partial nephrectomy and radical nephrectomy, where overall 10-year relative survival rates were 92.6% and 88.1%, respectively (p value =0.240). Subgroup analysis revealed NO significant difference in overall survival Except in patients with different age groups as seen in the table (p value Table: 216P Variables Survival of Patients p value Partial nephroectomy Radical nephroectomy Sex Male Female 96 % 89.7 % 87.9 % 88.3 % 0.821 Age 0- 9 10-19 20-39 40-59 60-79 91.5% 100% ** 100% ** 100% ** 100% ** 89.9% 71.8% 36.4% 100% 66.7% *** Race White 91% 100% _ * % _ * % 88.8% 86.1% 88.9% 83.3% 0.574 Black American Indian/Alaska Asian/pacific Islander Laterality Right left Bilateral 89.9% 92.9% 95% 90.1% 85.8% 92% 0.175 *** Highly significant P-value ≤ 0.001. ** few no. of cases _. * no recorded patients. Conclusions There is NO significant difference in overall 10-year survival between partial nephrectomy and radical nephrectomy. So, we recommend the application of partial nephrectomy in the appropriate patients to preserve as much kidney tissue and function as possible especially in bilateral WT. Further studies should be conducted on larger number of patients and they should study the efficacy of chemotherapy in patients undergoing partial nephrectomy. Legal entity responsible for the study Mira Mohamed Mostafa. Funding Has not received any funding. Disclosure All authors have declared no conflicts of interest.