Attenuating the DNA damage response to double-strand breaks restores function in models of CNS neurodegeneration

Abstract

DNA double strand breaks feature in neurological disorders, including many forms of neurodegeneration, stroke and acute neurotrauma. Tuxworth et al. show that inhibiting the DNA damage sensing response is neuroprotective, axon regenerative and improves functional recovery in models of neurodegeneration and optic nerve and spinal cord injury.