The Efficacy of Herbal Tea (non-camellia sinensis) on Glucose Homeostasis and Serum Lipids in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis (FS15-05-19).

Abstract

Objectives\nA meta-analysis systematic review that investigates the impact of the herbal tea (non-camellia sinensis) on glucose homeostasis and serum lipids in individuals with type 2 diabetes was conducted in response to a growing interest in herbal remedies as a potential alternative source of management of type 2 diabetes. Diabetes mellitus (DM) is a metabolic disorder that has contributed to the US burden of morbidity, disability and mortality with a fast-increasing global trend through the last decades.\n\n\nMethods\nPubMed, FSTA, Web of Science, CINAHEL and MEDLINE databases were searched using keywords diabetes* OR diabetes mellitus OR type 2 OR blood glucose OR insulin* OR antidiabet* OR glucose level ) AND ( Serum lipids OR triglyceride* OR cholesterol* OR LDL OR HDL OR dyslipidemia) AND ( non-camellia sinensis OR tea) up to January 2019. Review articles, animal studies, non-trial, non-herbal tea (green, black and white tea), and articles which did not evaluate glucose homeostasis and lipid profiles were included in the exclusion criteria. Articles that met the inclusion criteria included herbal tea administration effects on glucose homeostasis and serum lipids in clinical trials. All statistical calculations were performed using SAS software version 9.2 (SAS, Cary NC, USA).\n\n\nResults\nFrom 265 studies eight trials were included in the meta-analysis of glycemic and serum lipid profile end points. According to meta-analysis outputs, the estimated value for pooled fasting blood glucose (FBG) was -6.17 mg/dl, 95% CI: -19.96 to 7.6054, p value\xa0=\xa00.37; HbA1c (2.70, 95% CI: -1.1 to 6.5, p\xa0=\xa00.1), total-cholesterol (TC) (-10.896 mg/dl, 95% CI: -65.68 to 43.88, p\xa0=\xa00.69), LDL-cholesterol (LDL) (-8.57 mg/dl, 95% CI: -22.42 to 5.27, p\xa0=\xa00.22). The overall effects for triglyceride (TG) (-24.18 mg/dl, 95% CI: -42.69 to -5.68, p\xa0=\xa00.01) was significantly reduced by tea administration and HDL-cholesterol (HDL) (2.823 mg/dl, 95% CI: 9.7866 to 15.433 p\xa0=\xa00.05) significantly increased in the meta-analysis study.\n\n\nConclusions\nThe systematic review and meta-analysis supports a significant effect of herbal tea on triglyceride levels and HDL levels in individuals with type 2 diabetes. Additional clinical trials with a larger number of participants are needed as the number of studies is limited.\n\n\nFunding Sources\nN/A.