Intakes of Vitamin a and Zinc and Markers of Oxidative Stress in Newly Diagnosed HIV-positive Participants in the MASH Cohort in Miami (P24-016-19).

Abstract

Objectives\nHIV infection is characterized by increased oxidative stress. We examined the association of antioxidant intake with measures of oxidative stress and HIV disease progression in newly diagnosed HIV-infected participants.\n\n\nMethods\nCross-sectional study of 52 newly-diagnosed HIV-positive participants in the MASH cohort. Blood was drawn for parameters of oxidative stress (oxidized glutathione % and oxidative mitochondrial DNA damage [8-oxo-dG]) and disease stage (CD4- cell counts; HIV-viral load). Questionnaires on demographics and 24-hour dietary recalls and Alcohol Use Disorders Identification Test (AUDIT) were administered. AUDIT scores\xa0≥\xa08 was considered hazardous drinking. Dietary intakes of vitamin A and Zinc were calculated. SPSS was used for analyses and Linear Regression Models were estimated.\n\n\nResults\nParticipants were 74% male, 75% Black Non-Hispanic, and 21% Hispanics. Mean age was 42.3\xa0±\xa0SD10.2 years, CD4 count was 506.7\xa0±\xa0SD733.4 cells/µLA cross-sectional and HIV viral load was 3.63\xa0±\xa0SD1.23log10 copies/mL. Dietary intake of vitamin A (β\xa0=\xa0-0.001, SE\xa0=\xa00.0002, P\xa0=\xa00.044) and zinc (β\xa0=\xa0-0.0004, SE\xa0=\xa00.0002, P\xa0=\xa00.044) were inversely related with mitochondrial DNA damage (8-oxo-dG), after adjusting for education, race, age, gender, and excessive alcohol use. Oxidized glutathione percentage was directly associated with HIV-viral load (β\xa0=\xa00.81, SE\xa0=\xa00.4, P\xa0=\xa00.037) adjusting for age, gender, AUDIT\xa0≥\xa08 and BMI in linear regressions.\n\n\nConclusions\nLower intake of vitamin A and Zinc were associated with higher oxidative stress and higher HIV viral load. These findings suggest that antioxidant supplementation may be beneficial immediately after receiving a diagnosis of HIV infection as well as during antiretroviral treatment.\n\n\nFunding Sources\nFunded by the National Institute on Drug Abuse and the National Institute of Health.