Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | 2019
Changes in Bone Mass After Discontinuation of Pre-Exposure Prophylaxis (PrEP) with Tenofovir Disoproxil Fumarate/Emtricitabine in Young Men Who Have Sex With Men: Extension Phase Results of Adolescent Trials Network Protocols 110 and 113.
Abstract
HIV-seronegative men who have sex with men aged 15-22 years who lost bone mineral density (BMD) during TDF/FTC PrEP experienced partial or full BMD recovery 48 weeks following PrEP discontinuation, except lumbar spine and whole body BMD Z-scores remained below baseline 48 weeks off PrEP in participants aged 15-19 years.