The Overton window and a less dogmatic approach to antibiotics.

Abstract

IMPORTANCE\nRecent trials in infectious disease have led to reconsidering traditional treatment of infectious disease-changing the duration or type of traditional antibiotics or evaluating new antibiotics for approval. These trials have used the non-inferiority trial approach. The non-inferiority trial design and recent infectious disease trials of relevance are discussed in this viewpoint.\n\n\nOBJECTIVE\nTo analyze recent trials in infectious disease and consider needs for future trials.\n\n\nDESIGN\nViewpoint related to recent infectious disease trials.\n\n\nSETTING\nNot applicable.