Abstract 1: T Cells Contribute To Peripheral Nerve Regeneration Through Acellular Nerve Allografts Via Regulation Of Il-4

Abstract

PURPOSE: Peripheral nerve injury remains a significant public health issue. Traumatic nerve injuries often necessitate surgical repair with nerve grafts. While autologous nerve grafts are the clinical standard, acellular nerve allograft (ANAs) have been increasingly used. ANAs are prepared from nerve obtained from deceased donors treated with detergents to remove cellular debris and antigenic components. While it has the advantage of being available off-the-shelf, its ability to promote axon regeneration across a long nerve gap is limited. In this study, we evaluate why nerve regeneration across long ANAs is limited.