Plastic and Reconstructive Surgery Global Open | 2019
Abstract 88: Local Delivery of FK506 to a Mouse Sciatic Nerve Injury Increases Nerve Regeneration Outcomes
Abstract
RESULTS: 45 patients were included (14 female, 31 male). Mean age was 25.4 (16–40) years and mean BMI was 28.1 (22–40). 17 returned for follow-up physical exam, and 15 had pre-operative PROs available. Mean examination follow-up was 2.6 years, and mean PRO follow-up was 3.2 years. Knee ROM did not differ between the operated and unoperated knee. When comparing preand post-operative scores, statistically significant donor site morbidity was detected on KOOS subscales (n=15; Pain: -5.3 points, p=0.002; Activities of Daily Living [ADL]: -2.5 points, p=0.008; Sports and Recreation: -13 points, p=0.002) and WOMAC (n=15; -3.4%, p=0.009). Changes in other scales and subscales were not statistically significant. When controlled for age and sex, higher BMI was predictive of worse postoperative function on the KOOS Pain and Symptoms subscales, as well as WOMAC scale (p<0.05).