PD09-12\u2003UROLOGICAL MALIGNANCIES AND BONE MARROW TRANSPLANT FROM HLA APLOIDENTICAL DONOR: WHICH IS THE RELATIONSHIP?

Abstract

INTRODUCTION AND OBJECTIVES: Primary aim of the study was to analyze the incidence of urological secondary neoplasms in patients undergone bone marrow transplant from Hla aploidentical donor for haematological cancer. Secondary aim was to investigate the potential relationship between bone marrow transplant from Hla aploidentical donor and secondary urological malignancies. METHODS: Patients undergone aploidentical transplantation t-reg and t-con were prospectively enrolled from September 2008 to 2018 at the Institute of Hematology and marrow transplantation of the Santa Maria della Misericordia hospital in Perugia. Those who had previous or synchronous malignancies were excluded. The demographic and pathological data were retrospectively analyzed focusing on the age at the time of tumor diagnosis, the haematological disease that led to bone marrow transplantation, the timing between the transplantation and the urological tumor diagnosis, the histological type, the immunosuppressive regimen, any episode of rejection, the age and sex of the donor, any early and late complication and finally the cancer specific survival related to haematological and urological cancer. RESULTS: All data were resumed in table. 179 patients (86 female and 93 male) were included. Of these, 17 (24%) underwent TURB for bladder cancer. Histologic examination revealed 16 cases of low-grade urothelial carcinoma and a single case of recurrence of lymphatic acute leukemia with atypical localization. These secondary bladder neoplasms arose after mean time of 30.7 months (3-77) from bone marrow transplantation. The Wilcoxon test revealed that the patients undergoing bone marrow transplantation had a significant correlation with the development of bladder cancer (p= 0.011). CONCLUSIONS: To our knowledge, for the first time, we evaluated the incidence of urological tumor secondary to bone marrow transplantation for haematological cancer. We found a correlation between this type of patient and the development of secondary bladder cancer. Table. No title available. Source of Funding: None