MP51-20\u2003LONG NONCODING RNA DANCR FACILITATES METASTASIS AND PROLIFERATION IN BLADDER CANCER CELLS BY ACTIVATING IL-11-STAT3 SIGNALING

Abstract

putative binding sites with miR-149. Further experimental results demonstrated that DANCR functions as a miRNA sponge to positively regulate MSI2 expression by sponging the miR-149. Furthermore, overexpression of MSI2 reversed the malignant phenotype inhibition induced by silencing DANCR. CONCLUSIONS: Taken together, DANCR is a promising novel prognosis biomarker in bladder cancer. That DANCR promotes bladder cancer growth and metastasis through regulating MSI2 may represent a target for clinical intervention.