MP79-13\u2003ANALYSIS OF URETERAL STENTS ENCRUSTATION AND BIOFILM FORMATION AFTER 3-WEEK DWELL TIME: RESULTS OF A PROSPECTIVE RANDOMIZED MULTICENTRE CLINICAL COMPARATIVE STUDY OF SILICONE HYDROCOATED (IMAJIN® HYDRO) VERSUS PERCUFLEX™ PLUS

Abstract

INTRODUCTION AND OBJECTIVES: Silicone was one of the first materials to be used for ureteral stents. Importantly, silicone has been shown to be highly biocompatible and less prone to encrustation than polyurethane in a large series of removed ureteral stents. Since encrustation remains a significant concern when stents are implanted, we investigated these properties of silicone through a randomized multicenter study. METHODS: We performed a multicentre, prospective, randomized, single blind, comparative study of silicone hydrocoated ureteral stents versus PercuflexTM Plus, in patients treated by F-URS for a kidney stone. The studies had ethical committee approval in the respective hospitals. Primary endpoint was USSQ pain score after 3-week dwell. Ureteral stent encrustation and biofilm formation at removal was evaluated through a scoring scale (Table 1). Comparison was performed using ANOVA. RESULTS: 119 stents were available after removal for analysis, 56 in the silicone and 63 in the Percuflex TM Plus group. Mean dwell duration was 21.8 days for silicone, 22.1 days for PercuflexTM Plus. Biofilm and mineral encrustations were evaluated through optical microscopy of inner and outer surfaces of tips, angles and along the stents body. There was significantly more mineral encrustation and biofilm (Table 2) on PercuflexTM Plus on both renal and vesical tips and angle surfaces compared to silicone. Mean global biofilm and mineral encrustation were also more significant on PercuflexTM Plus stents. Five silicone stents had no encrustation at all, compared to none stent for PercuflexTM Plus. Two silicone stents had neither biofilm nor encrustation (none for PercuflexTM Plus). CONCLUSIONS: This multicentre randomized study evidences that silicone hydrocoated stents are less encrusted than PercuflexTM Plus after 3-week dwell time and confirms the low encrustation potential of silicone. Table. No title available. Table. No title available. Source of Funding: This study was supported by Coloplast.