P0752 / #2039: CHILDREN REQUIRING INTENSIVE CARE WITH SARS-COV-2 INFECTION DURING THE FIRST WAVE OF PANDEMIC IN SPAIN: A MULTI-CENTRE NATIONAL REGISTRY.

Abstract

AIMS & OBJECTIVES: Describe the characteristics of children admitted to Pediatric Intensive Care Units (PICUs) with SARS-COV-2 infection during the first wave of pandemic in Spain METHODS: A Multicentric prospective national registry was carried out 47 Spanish PICUs participated in the study Features from children admitted to PICUs with confirmed SARS-COV-2 infection or fulfilling multisystem inflammatory syndrome temporally associated with COVID-19 (MIS-C) criteria were collected RESULTS: 74 patients were included in the registry 61% of them presented with MIS-C features Patients not presenting with MIS-C features presented more frequently with respiratory distress (60 7% vs 13 3%, p<0 001) and less frequently with shock (13 8% vs 84 4%, p<0 001) or cardiac dysfunction (10 3% vs 53 3%, p=0 001) and usually had previous health conditions (48 3% vs 11 8%, p=0 005) and were younger ((3 4 years (IQR 0 4-9 4) vs 9 4 years (IQR 5 5-11 8), p=0 002) Three patients included in the registry died, they all had previous health conditions and none presented with MIS-C features The group presenting with MIS-C had lower mortality (0% vs 10 3%, p=0 056) and needed less frequently invasive ventilation (13 3% vs 41 4% p=0 005) than patients not presenting with MIS-C CONCLUSIONS: Although SARS-COV-2 severe infection is much more infrequent in children than in adults, some children present with severe disease requiring PICU admission In Spain, MIS-C was the most frequent presentation The course in this group of patients is usually more favorable compared to those patients without MIS-C