Systemic autoimmune diseases and recurrent pregnancy loss: research progress in diagnosis and treatment

Abstract

To the Editor: Recurrent pregnancy loss (RPL) is defined as the loss of two or more pregnancies before 24 weeks of gestation, and it affects about 1% to 2% of couples. The etiology of RPL includes metabolic/endocrinological abnormalities, genetic factors, anatomical factors, immune disorders, thrombophilia, male factors, and psychological factors. Systemic autoimmune diseases like antiphospholipid syndrome (APS), undifferentiated connective tissue disease (UCTD), and systemic lupus erythematosus (SLE) have been found to be important causes of RPL in recent years. Understanding the associations between different systemic autoimmune diseases and RPL, as well as being able to provide suitable diagnoses and treatments, is of great significance.