Basal septal hypertrophy in hypertension; about time to introduce an objective and reproducible quantification.

Abstract

S ubclinical left ventricular (LV) dysfunction, abnormal LV geometry, such as LV hypertrophy (LVH) and concentric remodeling, and left atrial remodeling are the key components of hypertensive heart disease by increased arterial load [1]. Although the association between the duration and severity of hypertension and abnormal LV geometry is well known, other factors, such as genetic, metabolic and environmental factors may be also equally important [2]. LVH may be eccentric or concentric, or only involve interventricular septum either the whole septum (isolated septal hypertrophy) or the basal/upper part (Fig. 1). The regional myocardial function assessed by strain is clearly decreased in LV segments with basal septal hypertrophy (BSH). Traditionally, BSH, also termed sigmoidal septum, is visually assessed by echocardiography and is not included in the conventional classification of LVH types. International guidelines on cardiac chamber quantification by echocardiography in adults, recommend measurement of interventricular septum immediate below the septal bulge assessed by linear method because of the risk of overestimation of the true LV mass [3,4], or even in mid-septal level, which has best agreement with cardiac magnetic resonance (CMR) in patients with aortic stenosis and BSH [5]. Of note, three-dimensional CMR incorporates regional differences in LV wall thickness, and therefore provides more accurate measurements. In some patients, particularly in elderly women, patients with aortic stenosis, systemic hypertension and increased arterial stiffness, or individuals with smaller LV cavity dimensions and high-normal LV ejection fraction, BSH may increase the risk of dynamic LV obstruction, even in the absence of underlying hypertrophic obstructive cardiomyopathy (Saeed et al. unpublished observation). Apart from the traditional visual assessment, BSH can be also defined by a somehow more quantitative method of basal-to-mid-septal thickness ratio of more than 1.4 in either parasternal long-axis view or apical four-chamber view. This method, however, has limited reproducibility. The use of a single echocardiographic view to measure basalt-tomid septal ratio may not be appropriate as some patients with hypertension or metabolic syndrome may have a proportionate septal hypertrophy without a typical bulging on parasternal long-axis view but show a prominent midseptal bulging on apical four-chamber view (Fig. 2). The clinical significance and prognostic value of BSH were not known for a long time, probably because of lack of a more robust, objective and reproducible method for characterization and quantification of BSH. However, the data on the clinical significance of BSH is now emerging. Most recently, an association between BSH and impaired LV function, and LV and left atrial remodeling was documented in hypertensive patients [6]. The authors postulated that BSH might be an early marker of hypertension-induced LV remodeling. Hence, this implies a more detailed assessment and quantification of BSH with more objective and reproducible methods. In this issue of the Journal of Hypertension, Marciniak et al. [7] introduced a novel method for assessing BSH. The LV endocardium curvatures were used for characterization and quantification of BSH in a cohort of 220 individuals including 161 hypertensive patients and 59 healthy controls, with a 20% prevalence of BSH. The average septal curvature (ASC) is calculated from a well established and widely available endocardial segmentation tool, which is used to assess strain by echocardiography. Patients with BSH are more concave in the BSH segment and reports a more negative ASC compared with patients without BSH. The ASC method might look complicated at the first look but can be performed fully automatized and seemed to be a robust and objective echocardiographic measure of BSH with good reproducibility. Given its higher reproducibility compared with the traditional visual assessment of BSH or the quantitative method of basal-to-mid-septal thickness ratio, easy interpretation and the potential for implementation in 3D-imaging modalities, ASC seem to be a promising Journal of Hypertension 2021, 39:1316–1318 Department of Heart Disease, Haukeland University Hospital, Bergen, Department of Cardiology, Oslo University Hospital, Rikshospitalet and Institute for clinical medicine, University of Oslo, Oslo, Norway