Editorial Comment.

Abstract

Utilizing ClinicalTrials.gov and publication data from MEDLINE, this study evaluates 12 years of data on urology trial registration to investigate early discontinuation, reported results and publication rates. More than 300,000 trials were reviewed, with 4% urology related trials, classified as academic (53%), industry (37%) or governmentsponsored (10%). Of the studies 41% reached completion, 11.6% were discontinued and 38% were ongoing. Only 26.9% of completed trials reported registry results, with government and industry outperforming academic-sponsored trials. Alarmingly, only 21% of trials published, which did not differ by urology subspecialty. Poor accrual was the most common reason for discontinuation, with academics and government-sponsored frequently citing budget shortages. Importantly, this study highlights discrepancies between effort and results when it comes to clinical trials in urology and the inherent challenges with UROLOGY OUTCOMES IN CLINICALTRIALS.GOV 1167