The Effects of Hemodynamic Unloading in African Americans Implanted with Left Ventricular Assist Devices

Abstract

We aim to evaluate the echocardiographic/hemodynamic effects of left ventricular assist devices in African American (AA) versus non-AA patients undergoing ramp speed optimization and its subsequent effect on readmissions. In 65 patients (26 AA), no differences in baseline echocardiographic/hemodynamic parameters were noted. During ramp testing, there was a significantly greater increase in cardiac output (slope: 0.29\u2009±\u20090.24 vs. 0.15\u2009±\u20090.12, p < 0.01) with more rapid decrease in left ventricular end-diastolic diameter (slope: −0.21\u2009±\u20090.14 vs. −0.13\u2009±\u20090.07\u2009L/min, p < 0.01) in the AA group. AAs had higher all-cause, but similar heart failure readmission rate as compared with the non-AA group.