Prognostic value of angiopoietin-2 for patients with coronary heart disease after elective PCI

Abstract

Abstract Patients with coronary heart disease (CHD) frequently have cardiovascular complications after undergoing PCI. Angiopoietin-2 (Ang-2) is an important proangiogenic factor that also plays an important role in atherosclerosis. This study aimed to evaluate the value of Ang-2 in predicting cardiovascular events after elective PCI. This prospective study enrolled 97 patients with CHD who underwent elective PCI from 2013 to 2014. Blood samples were collected in the first morning after admission and within 24 to 48\u200ah after PCI. The primary endpoint was cardiovascular events, defined as a composite of cardiac death, nonfatal myocardial infarction/repeat revascularization, readmission for severe deterioration of angina and readmission for new onset heart failure. Based on the median level of pre-PCI or post-PCI Ang-2, the patients were divided into a low level group and a high level group. During the whole follow-up period (mean, 53\u200a±\u200a13\u200amonths), Kaplan–Meier curves of cardiovascular events showed that there was no significant difference between the two pre-PCI groups (&khgr;2\u200a=\u200a2.22, P\u200a=\u200a.137, and log-rank test) or the two post-PCI groups (&khgr;2\u200a=\u200a2.83, P\u200a=\u200a.093, and log-rank test). However, in a multivariable Cox regression model, landmark analysis showed that the patients in high level group of post-PCI, not pre-PCI, were associated with remarkable higher risks of cardiovascular events compared to the low level group during the first 1.5\u200ayears of follow-up (adjusted HR\u200a=\u200a9.99, 95%CI\u200a=\u200a1.99–50.13, P\u200a=\u200a.005). However, that was of no significance from 1.5\u200ayears to maximum follow-up years (adjusted HR\u200a=\u200a0.82, 95%CI\u200a=\u200a0.26–2.59, P\u200a=\u200a.733). High Ang-2 levels of post-PCI can predict the occurrence of cardiovascular events in the short to medium term.