Ketorolac plus Lidocaine vs Lidocaine for pain relief following core needle soft tissue biopsy

Abstract

Abstract Backgrounds: The main objective of this study was to compare the pain control efficacy of local administration of Lidocaine with or without the nonsteroidal anti-inflammatory drug, Ketorolac, and local conventional Lidocaine injection in core needle biopsy of the musculoskeletal tumor. Methods: The current study was a randomized, double-blind controlled clinical trial that included 128 patients with suspected musculoskeletal tumors. Patients were randomly assigned to either the Ketorolac plus Lidocaine (n\u200a=\u200a64) or Lidocaine group (n\u200a=\u200a64). The Ketorolac – Lidocaine combination syringe contained 30\u200amg Ketorolac and 2% Lidocaine – adrenaline dosage, and the Lidocaine syringe contained 2% Lidocaine – adrenaline dosage. The level of pain after core needle biopsy was evaluated for each patient at 1, 6, 12, 24, 48, and >48\u200ahours by a Visual Analog Scale (VAS). The mean VAS changes over time were compared between the Ketorolac plus Lidocaine and Lidocaine groups using a linear mixed model. Results: baseline information including mean age of patients in Lidocaine group (51.5\u200a±\u200a19.4\u200ayears) and in Lidocaine – Ketorolac combination group (50.1\u200a±\u200a18\u200ayears), diagnosis (malignant, benign, metastatic, infection), tumor location (upper and lower extremities, back), VAS score 1-hour post-operation (mild and moderate pain) were noted. The VAS score ratings were significantly lower in Lidocaine – Ketorolac combination group when compared to the Lidocaine group during the 1 to 24\u200ahours post-operation time period. Conclusion: Patients receiving Lidocaine – Ketorolac combination dosage had significantly lower VAS scores, and these results confirm that local injection of Lidocaine – Ketorolac combination had a superior pain-controlling effect during the first 24\u200ahours after the biopsy procedure in comparison to Lidocaine injection alone, as measured by VAS score scale.