Human immunodeficiency virus case detection and antiretroviral therapy enrollment among children below and above 18\u200amonths old

Abstract

Abstract While pediatric human immunodeficiency virus (HIV) testing has been more focused on children below 18\u200amonths through prevention of mother to child transmission of HIV (PMTCT), the yield of this approach remains unclear comparatively to testing children above 18\u200amonths through routine provider-initiated testing and counselling (PITC). This study aimed at assessing and comparing the HIV case detection and antiretroviral therapy (ART) enrolment among children below and above 18\u200amonths of age in Cameroon. This information is required to guide the investments in HIV testing among children and adolescents. We conducted a cross-sectional study where we invited parents visiting or receiving HIV care in 3 hospitals to have their children tested for HIV. HIV testing was done using polymerase chain reaction (PCR) and antibody rapid tests for children <18\u200amonths and those ≥18\u200amonths, respectively. We compared HIV case detection and ART initiation between the 2 subgroups of children and this using Chi-square test at 5% significant level. A total of 4079 children aged 6 weeks to 15\u200ayears were included in the analysis. Compared with children <18\u200amonths, children group ≥18\u200amonths was 4-fold higher among those who enrolled in the study (80.3% vs 19.7%, P\u200a<\u200a.001); 3.5-fold higher among those who tested for HIV (77.6% vs 22.4%, P\u200a<\u200a.001); 6-fold higher among those who tested HIV+ (85.7% vs 14.3%, P\u200a=\u200a.24), and 11-fold higher among those who enrolled on ART (91.7% vs 8.3%, P\u200a=\u200a.02). Our results show that 4 out of 5 children who tested HIV+ and over 90% of ART enrolled cases were children ≥18\u200amonths. Thus, while rolling out PCR HIV testing technology for neonates and infants, committing adequate and proportionate resources in antibody rapid testing for older children is a sine quo none condition to achieve an acquired immunodeficiency syndrome (AIDS)-free generation.