Baseline neutrophil-lymphocyte ratio is associated with outcomes in patients with castration-resistant prostate cancer treated with Docetaxel in South China

Abstract

Abstract The aim of this study is to investigate the association between baseline neutrophil-to-lymphocyte ratio (NLR) and progression-free survival (PFS), overall survival (OS) and radiological response in castration-resistant prostate cancer patients treated with docetaxel. Forty-one prostate cancer patients who were treated with docetaxel were selected. Univariable and multivariable Cox regression models were used to predict the association of baseline NLR as a dichotomous variable with PFS and OS after chemotherapy initiation. In Kaplan–Meier analysis, the median PFS (9.8 vs 7.5\u200amonths, P = .039, Fig. 1) and OS (17.6 vs 14.2\u200amonths, P\u200a=\u200a.021, Fig. 2) was higher in patients who did not have an elevated NLR than in those with an elevated NLR. In univariate analysis, the pretreatment NLR was significantly associated with PFS (P\u200a=\u200a.049) and OS (P\u200a=\u200a.023). In multivariable analysis, patients with a NLR of >3 were at significantly higher risk of tumor progress (hazard ratio 2.458; 95% confidence interval 1.186–5.093; P\u200a=\u200a.016) and death (hazard ratio 3.435; 95% CI 1.522–7.750; P\u200a=\u200a.003)than patients with a NLR of ⩽3. NLR may be an independent predictor of PFS and OS in castration-resistant prostate cancer patients treated with docetaxel. The findings require validation in further prospective, big sample-sized studies.