Systematic Review and Meta-analysis of Minimally Invasive Pancreatectomies for Solid Pseudopapillary Neoplasms of the Pancreas

Abstract

Objectives We report the first systematic review and meta-analysis on minimally invasive pancreatectomy (MIP) for solid pseudopapillary neoplasms (SPPN) of the pancreas. Methods A systematic review of all studies reporting patient characteristics and outcomes of MIP for SPPN was conducted. Results We reviewed 27 studies comprising 149 patients with SPPN managed via MIP. Five were comparative retrospective cohort studies, comprising 46 and 60 patients in the minimally-invasive and open groups, respectively. Tumor size was smaller in the minimally-invasive group (mean difference, −2.20; 95% confidence interval (CI), −3.09 to −1.32; P < 0.001). The MI group had lower intraoperative blood loss (mean difference, −180.19; 95% CI, −344.28 to −16.09; P = 0.03) and transfusion requirement (relative risk, 0.24; 95% CI, 0.06–0.94; P = 0.04), and a shorter time to diet (mean difference, −2.99; 95% CI, −3.96 to −2.03; P < 0.001) and length of stay (mean difference, −3.61; 95% CI, −6.98 to −0.24; P = 0.04). There was no significant difference in operating time, margin positivity, postoperative morbidity, and postoperative pancreatic fistula rates. Conclusions Minimally invasive pancreatectomy for SPPN is associated with decreased intraoperative blood loss and transfusion requirements and a shorter postoperative time to diet and hospital stay.