20-Year Follow-up Study of Celiac Patients Identified in a Mass School Screening: Compliance to Gluten-Free Diet and Autoimmunity.

Abstract

OBJECTIVES\nTo investigate the compliance to the gluten-free diet in a cohort of adult celiac patients 20\u200ayears after the diagnosis, received in childhood through a mass screening.\n\n\nMETHODS\nThis is an observational historic cohort follow-up study. It was carried out at the Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy. Two matched cohorts of adult celiac patients, diagnosed in childhood through a mass screening or for symptoms were enrolled. Adherence to the gluten free-diet and development of autoimmune diseases were investigated through a questionnaire administrated in the course of a phone interview.The primary study outcome was the adherence to the gluten-free diet, measured through the Biagi questionnaire, in the two cohorts of celiac patients.\n\n\nRESULTS\nWe contacted 25 patients (mean age 28 yrs, 19 females) diagnosed with screening and 34 patients (mean age 25 yrs, 26 females) diagnosed in the same period for symptoms. After 20\u200ayears, in the cohort diagnosed with screening and in the cohort diagnosed for symptoms the adherence to the gluten-free diet was optimal in 14 (56%) and 26 (81%), improvable in 5 (20%) and 3 (9%), inadequate in 6 (24%) and 3 (9%), respectively. In the two cohorts, 4 patients (16%) and 6 patients (18%) developed other autoimmune diseases.\n\n\nCONCLUSIONS\n20\u200ayears after the diagnosis, near half of the patients diagnosed in a mass screening, does not have an optimal adherence to the gluten-free diet and a remarkable proportion of them have developed another autoimmune disease.