Kidney injury biomarkers during exposure to tenofovir-based pre-exposure prophylaxis.

Abstract

ABSTRACT\nWe previously reported a higher incidence of non-albumin proteinuria and a small but significant decline in estimated glomerular filtration rate among HIV-negative adults randomized to emtricitabine/ tenofovir disoproxil fumarate pre-exposure prophylaxis (FTC/TDF PrEP) versus placebo. In a nested case-control study among participants randomized to FTC/TDF PrEP, established kidney injury biomarkers measured at 12\u200amonths were not significantly different between subjects who subsequently experienced one of these kidney endpoints and randomly selected controls who did not.