Annals of surgery | 2021
Intravenous Local Anesthetic Compared with Intraperitoneal Local Anesthetic in Laparoscopic Colectomy: A Double-Blind Randomized Controlled Trial.
Abstract
INTRODUCTION\nControlling perioperative pain is essential to improving patient experience and satisfaction following surgery. Traditionally opioids have been frequently utilised for postoperative analgesia. Although they are effective at controlling pain, they are associated with adverse effects, including postoperative nausea, vomiting, ileus and long-term opioid dependency.Following laparoscopic colectomy, the use of intravenous or intraperitoneal infusions of lidocaine (IVL, IPL) are promising emerging analgesic options. Although both techniques are promising, there have been no direct, prospective randomized comparisons in patients undergoing laparoscopic colon resection. The purpose of this study was to compare IPL with IVL.\n\n\nMETHODS\nDouble blinded, randomized controlled trial of patients undergoing laparoscopic colonic resection. The two groups received equal doses of either IPL or IVL which commenced intra-operatively with a bolus followed by a continuous infusion for 3\u200adays postoperatively. Patients were cared for through a standardized ERAS program. The primary outcome was total post-operative opioid consumption over the first three post-operative days. Patients were followed for 60\u200adays.\n\n\nRESULTS\nFifty-six patients were randomized in a 1:1 fashion to the IVL or IPL groups. Total opioid consumption over the first three post-operative days was significantly lower in the IPL group (70.9\u200amg vs 157.8\u200amg p < 0.05) and overall opioid consumption during the total length of stay was also significantly lower (80.3\u200amg vs 187.36\u200amg p < 0.05. Pain scores were significantly lower at two hours post-operatively in the IPL group, however, all other time points were not significant. There were no differences in complications between the two groups.\n\n\nCONCLUSION\nPerioperative use of IPL results in a significant reduction in opioid consumption following laparoscopic colon surgery when compared to IVL. This suggests that the peritoneal cavity/compartment is a strategic target for local anesthetic administration. Future ERAS recommendations should consider IPL as an important component of a multimodal pain strategy following colectomy.