Epidemiology and antibiotic resistance profile of Helicobacter pylori infection in Cameroon: a systematic review with meta-analysis

Abstract

Objectives Although global epidemiology of Helicobacter pylori (HP) infection is well characterized, country specific figure is more accurate for context specific tailored interventions. The aim was to determine the prevalence, factors associated with infection, antibiotic resistance profile, and genotypes of HP in Cameroon. Design A systematic review with meta analysis. Participants People living in Cameroon regardless of their clinical profile. Data sources and synthesis Observational studies published in PubMed, EMBASE, African Index Medicus, African Journals Online, and Health Sciences and Diseases up to October 12th, 2020. Study selection, data extraction, and methodological quality assessment were done by two independent authors. Random effect meta analysis served to pool prevalence data. Results Fifteen studies were included. None investigated the genotypes of HP. Among symptomatic patients, the most common used test, urea breath test on gastric biopsy, yielded a prevalence 57.8% (95% confidence interval (CI): 34.3; 79.5) of HP infection. This prevalence significantly varied between 47.0% (95%CI: 43.0; 51.0) for antigen test in stool samples and 71.2% (95%CI: 59.1; 81.9) for Giemsa on gastric biopsy; p = 0.0006. One study in asymptomatic children reported the prevalence of 52.3% (95%CI: 44.9; 59.6) using antigen test for stool samples. Among the six studies investigating factors associated with HP infection, one performed a multivariable model and identified being student as protective factor compared to being employed (Odds ratio: 0.09; 95%CI: 0.02; 0.49). For antibiotics used for first line treatment, HP was resistant to amoxicillin (85.6; 97.1%), metronidazole (93.2; 97.9%), and clarithromycin (13.6; 44.7%) as reported in two studies. Limitation Data were from six of the ten regions of Cameroon, hindering the generalizability of the findings to the country. Conclusion This study depicted a high prevalence of HP infection and a worrying resistance profile to first-line antibiotics. When waiting for well conducted studies, updated guidelines are needed for clinical practice for first line antibiotic treatment. Registration PROSPERO, CRD42020220084.