Integrative Wireless Device for Remote Continuous Blood Biomarker Monitoring

Abstract

To perform precision medicine in real-time at home, a device capable of long-distance continuously monitoring target biomolecules in unprocessed blood under dynamic situations is essential. In this study, an integrative buffer-free wireless device is developed to measure drug concentrations in patient’s blood in real time for remote clinical healthcare. To demonstrate its capability, the drug molecules (i.e., small-molecule drug doxorubicin, DOX) are continuously measured in the unprocessed whole blood of live animals (e.g., rats). The dynamic changes of drug concentrations with sub-minute temporal resolution are recorded for an extended period of time (∼8 hours). As an advance in remote diagnosis, this device would benefit the public by enabling long-distance precision medicine to prevent pandemics in advance.