bioRxiv | 2019

Disentangling neuronal inhibition and inhibitory pathways in the lateral habenula



The lateral habenula (LHb) is hyperactive in depression, and thus inhibition of this structure makes an interesting target for future antidepressant therapies. However, the circuit mechanisms mediating inhibitory signalling within the LHb are not well-known. We addressed this issue by studying LHb neurons expressing either parvalbumin (PV) or Neuron-derived neurotrophic factor (Ndnf), two markers of particular sub-classes of neocortical inhibitory neurons. In the LHb, we report that Ndnf is not representative of any particular neuronal sub-population. In contrast, we find that PV is expressed by multiple physiologically diverse sub-classes of LHb neurons. Furthermore, we identify two previously unknown distinct sources of inhibitory input arising from PV-positive neurons both locally, and from the medial dorsal thalamic nucleus. These findings hence provide new insight into inhibitory control within the LHb, and highlight that this structure is more neuronally diverse than previously thought.

Volume None
Pages None
DOI 10.1101/633271
Language English
Journal bioRxiv

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