Combined Multi-frequency Responsive Stimulation for Effective Seizure Suppression in Temporal Lobe Epilepsy Model

Abstract

Single-target responsive neural stimulation might underlie limited efficacy for seizure suppression since broad networks in the brain are involved in the epileptic activities. In order to improve the efficacy of seizure suppression, two main issues need to be further explored: 1) whether the combined multi-site stimulation within the epileptogenic network could alter the dynamics of the network more efficiently, and 2) how do the electrical stimulation parameters, especially frequency, impact the performance of seizure suppression. In our study, the efficacy of responsive stimulation with high frequency (130Hz, HFS) or low frequency (5 Hz, LFS) delivered to CA3, CA1, and subiculum of hippocampi and anterior nucleus of thalamus for seizure suppression was assessed by acute kindling in chronic temporal lobe epilepsy. Our results showed that frequencies did impact the efficacy of seizure suppression at same site. Moreover, the combined stimulation with optimized stimulation frequencies would reduce the severity of epilepsy significantly. The novel combination of responsive stimulation may be an inspiration to optimize stimulation therapy for epilepsy.