A 46-channel Vector Stimulator with 50mV Worst-Case Common-Mode Artifact for Low-Latency Adaptive Closed-Loop Neuromodulation

Abstract

Neural implants for closed-loop therapeutic neuromodulation – recording, processing, and delivering state and activity dependent neural stimulation to targeted regions of interest (ROIs) in the brain – are emerging as critical enablers of ground-breaking treatments of a wide range of neurological diseases and disorders. While existing systems [1 –4] deliver electrical stimulation by placing electrodes in close proximity to target neurons, the capability for low-latency configurable stimulation that is spatially localized remains unrealized. Meanwhile, architectures that enable uninterrupted recording, maintain high voltage compliance and achieve excellent charge balance remain critical for implantable stimulators.