Identification and Functional Inference for Tumor-Associated Long Non-Coding RNA

Abstract

Gastric cancer is one of the top leading causes of cancer mortality worldwide especially in China. In recent years, some lncRNAs are discovered to be dysregulated in many cancers. The study on long non-coding RNAs (lncRNAs) relationship with cancers has attracted increasing attention. The molecular mechanism of gastric cancer remains largely unclear factors, especially for lncRNAs. Experiments are feasible to obtain related information, however, experimental identification of cancer-related lncRNAs usually possesses high time complexity and high cost. In this paper, a computational method is proposed to determine the relationship between lncRNA and gastric cancer by reusing the exon-based array of gastric cancer. One specific lncRNAs LINC00365 and its target differentially expressed genes whose products are predicted as blood, urine, or salvia-excretory are identified to be candidates for a combined biomarker for gastric cancer. Further biological function and molecular mechanism of the gastric cancer related lncRNAs and coding gene biomarkers are inferred in terms of multi-source biological knowledge.