Design and Development of Pulse Power Generation System to Enhance Transdermal Drug Delivery to the Cell by Electroporation Technique

Abstract

In this paper, a pulse generator based electroporation system has been developed. The proposed model review a boost converter based pulse power generation technology which is able to generate a pulse across a resistive load. The concept of the proposed approach depends on operating the involved boost converter in discontinuous current conduction mode with high voltage gain and enhanced efficiency. This device generates high voltages for a short time to permeabilize the skin. This can be used to increase the scope of transdermal drug delivery to the cell. The proposed pulse power converter system could be divided into two part which is a gate driver and a boost converter. For produce a high pulse voltage, a pulse signal flow from the gate driver to boost converter. The initial target of this system is to generate a voltage above 145 volts. But the peak generated voltage is about 140 volts. The developed pulse power circuit can be used for the electroporation system which is widely used to enhance the transdermal drug delivery to the patient s cell.