Effect of Dialyzer Membranes on Mortality in Uremic Patients Undergoing Long-term Hemodialysis: A Nationwide Population-based Study using the Taiwan Dialysis Registry Data System 2005-2012.

Abstract

INTRODUCTION\nThe characteristics in dialyzer is associated with mortality in patients with end-stage renal disease (ESRD) receiving hemodialysis (HD). This study is to investigate the effects of dialyzer membranes on 3-year mortality in ESRD patients.\n\n\nMETHODS\nFrom the long-term nationwide population database database. Prevalent HD patient during 2005-2012 were enrolled. Our main analysis to calculate the effect was cox regression multivariate model.\n\n\nRESULTS\nOverall, the mean age of all population (N=73,565) was 61.0 ±\u200913.6\u2009years, observation period is 2.46\u2009years ±\u20090.98 within 3\u2009years and 64.6% used polysulfone (PS), polymethyl methacrylate (PMMA) (11.6%), polyethersulfone (11.4%), and cellulose triacetate (CTA) (10.7%), EVAL (Hazard ratio [HR] 2.72, 95% confidence interval [CI] 1.71-4.33) and CTA (HR 1.35, 95% CI 1.12-1.64) were associated with higher mortality than PS, but PMMA was not.\n\n\nCONCLUSION\nEVAL and CTA adversely affected mortality and PMMA had no protective role. Further investigations on membrane characters on HD patients are warranted. Taipei Medical University (TMU) (TMU-JIRB (No. N201804051).