Plasma volume and atrial natriuretic peptide during induction of anaesthesia

Abstract

We thank Dr Saito for the interest in our paper Effects of different mean arterial pressure targets on plasma volume, ANP and glycocalyx-A randomized trial where cardiac surgery patients were randomised to a mean arterial pressure (MAP) of 60 or 90 mm Hg using norepinephrine (NE) infusion.1,2 The plasma volume (PV) and the Mid Regional-pro Atrial Natriuretic Peptide (MR-proANP) increased in the group randomised to lower MAP. All patients had a normal left ventricular ejection fraction of 45% or more.