Unfinished business: Functional outcomes in a randomized controlled trial of a three-year extension of early intervention versus regular care following two years of early intervention for psychosis.

Abstract

OBJECTIVE\nTo investigate whether first-episode psychosis patients receiving extended early intervention (EI) had better functional outcomes than those in regular care and to examine the predictors of functional outcomes.\n\n\nMETHODS\nThis is a randomized controlled single-blind trial of\xa0220\xa0patients randomized\xa0after two years of EI to receive EI or regular care for the subsequent three years. Outcomes included cumulative time in functional recovery during the three-year trial assessed using the Social and Occupational Functioning Assessment Scale (SOFAS); and employment/education at last assessment which were respectively analysed using multiple linear regression and logistic regression, accounting for well-known predictors. Linear mixed and generalized linear models were also used to examine the course of SOFAS and employment/education over the three-year period.\n\n\nRESULTS\nThe extended EI and regular care groups did not differ on time in functional recovery (Mean=50.17 weeks; SD=46.62 vs. Mean=46.18 weeks; SD=51.54); percent employed/in school (60.4% vs. 68.8%) or change in SOFAS or employment/education status over time. SOFAS scores were stable between Years 2 and 5. Individuals with longer periods of total symptom remission experienced significantly longer periods of functional recovery and were likelier to be employed/in school. Those who had completed high school were nine times likelier to be employed/studying.\n\n\nCONCLUSION\nMost individuals maintained functional gains accrued from two years of EI with no further improvement whether in extended EI or regular care. There was a gap between symptomatic and functional recovery and one-third were unemployed/not in school at Year 5. The lack of additional progress even in extended EI suggests that specific interventions addressing functional roles need to be provided beyond the first two years of EI. Sustaining symptom remission and high-school completion may be additional avenues for targeting functional recovery.