Australasian Journal of Dermatology | 2019

Pseudoxanthoma elasticum: Dermoscopy and mutation analysis

 
 
 
 
 

Abstract


toid papulosis may serve as a herald to othermalignancies, with mycosis fungoides being the most common. Concerning pityriasis lichenoides, the presence of a dominant T-cell clone and the rare evolution into mycosis fungoides may be suggestive of a slight malignant potential, but this still remains controversial. In our case, the consecutive onset of lymphomatoid papulosis type-A, classic type mycosis fungoides, and pityriasis lichenoides et varioliformis acuta may further indicate a link between these clinical entities via a common network of multifunctional genes and pathways. According to what we believe, the most probable clinical scenario is that the appearance of pityriasis lichenoides et varioliformis acuta during pregnancy was facilitated by gestation-related immunosuppression. If the diseases are due to one underlying pathogenesis, such as lymphoproliferation, different alterations in host immunity may lead to discrete clinical expressions and thus different diseases at specific times during a patient’s lifetime. In conclusion, we report a patient diagnosed with mycosis fungoides, lymphomatoid papulosis, and pityriasis lichenoides et varioliformis acuta. This case highlights the probably common etiology of those three distinct entities, as well as the fundamental role of clinicopathological correlation during diagnosis.

Volume 60
Pages None
DOI 10.1111/ajd.12930
Language English
Journal Australasian Journal of Dermatology

Full Text