Pseudolymphoma induced by secukinumab for treatment of chronic plaque psoriasis

Abstract

cutaneous features of phacomatosis pigmentokeratotica. Generally, the epidermal and melanocytic proliferations remain as benign hamartomas; however, basal cell carcinoma and melanoma have been reported in each lesion, respectively. The HRAS c.37G>C (p.Gly13Arg) mutation has been described in malignant transformation in phacomatosis pigmentokeratotica previously. It is therefore precautionary to consider that identification of this mutation likely increases the risk of tumorigenesis in either lesion, with consequent appropriate long-term surveillance.