Detection of secondary choroidal neovascularization in chronic central serous chorioretinopathy by swept source‐optical coherence tomography angiography

Abstract

doi: 10.1111/aos.13855 Editor, C hronic central serous chorioretinopathy (CSCR) is characterized by persistent circumscribed elevation of the neurosensory retina due to subretinal fluid (SRF) accumulation. Up to one-third of eyes with chronic CSCR are complicated by the sequela of secondary choroidal neovascularization (CNV). Swept source-optical coherence tomography angiography (SS-OCTA) is a relatively new non-invasive imaging technology, which visualizes retinal and choroidal vasculature by measuring blood flow (Makita et al. 2006). Herein, the sensitivity and specificity of SS-OCTA for the detection of secondary CNV in chronic CSCR were evaluated. Thirty-five eyes of 24 patients (aged 54 11 years; 88% males) with the clinical diagnosis of chronic CSCR and visual symptoms for more than 6 months were enrolled between March and November 2016 and retrospectively reviewed at our tertiary eye care centre (Medical Retina Unit, Department of Ophthalmology; Rudolf Foundation Hospital Vienna; Karl Landsteiner Institute for Retinal Research and Imaging). Baseline analysis included slit-lamp biomicroscopy of the fundus (Haag-Streit AG, Bern, Switzerland), spectral domain (SD)OCT, blue-peak autofluorescence, fluorescein (FA) and indocyanine green angiography (ICGA; Spectralis High Resolution Angiography HRA+OCT Confocal Scanning Laser Ophthalmoscope; Heidelberg Engineering GmbH, Heidelberg, Germany) and best corrected visual acuity (BCVA) using back-illuminated Early Treatment Diabetic Retinopathy Study (0.94 0.35 ETDRS letters) charts starting at 4 m converted to Snellen (20/30 Sn). In addition, consenting patients were examined with a beta version of Topcon’s DRI Triton SSOCTA (Topcon Corporation, Tokyo, Japan) device (Fig. 1). The images were meticulously analysed by another retina specialist for the