Impact of glucagon-like peptide-1 receptor agonists on adiponectin concentrations: a meta-analysis of randomized controlled trials.

Abstract

AIM\nPrevious studies have reported an elevation in adiponectin concentrations using glucagon-like peptide-1 receptor agonists (GLP-1 RA) therapy; however, this possible pleiotropic effect is still uncertain. Thus, the objective of this meta-analysis of randomized controlled trials was to assess the impact of GLP-1 RA on adiponectin levels.\n\n\nMETHODS\nThis systematic review and meta-analysis included randomized controlled trials investigating the effect of GLP-1 RA on circulating adiponectin concentrations. Studies from PubMed, Web of Science, Scopus, and Google Scholar databases were included. A random-effects model and a sensitivity analysis using the leave one-out method were conducted.\n\n\nRESULTS\nA meta-analysis of 20 randomized controlled trials involving 1,497 individuals demonstrated a significant increase in adiponectin levels after GLP-1 RA administration (WMD: 0.59 μg/mL, 95% CI: 0.10, 1.08, p = 0.02). Particularly, liraglutide had a significant effect on adiponectin (WMD: 0.55 μg/mL, 95% CI: 0.04, 1.06, p = 0.04), while exenatide did not affect these concentrations (WMD: 0.60 μg/mL, 95% CI: -0.23, 1.42, p = 0.16).\n\n\nCONCLUSIONS\nGLP-1 RA treatment is associated with an increase in adiponectin levels.