ICD-11 mixed episode: Nothing new despite the evidence.

Abstract

The modern concept of mixed state was introduced by Kraepelin 1 to identify phases characterized by the contemporary presence of manic and depressive features, in patients with manic-depressive insanity. He formulated the hypothesis that each of the domains of mood, cognition, and activity would change at a different pace over time, thereby leading to selective increases or decreases of each of these three domains. This article is protected by copyright. All rights reserved.