Bipolar disorders | 2019
Lithium levels and treatment efficacy.
Abstract
Nolen et al1 systematically reviewed clinical trial literature on the optimal serum level for lithium in the maintenance treatment of bipolar disorder. They found that the quality of the identified trials did not support the formulation of evidence-based recommendations; only 7 appropriate trials were identified, and these, only after relaxation of each of the original 6 study selection criteria.