Blistering severe cutaneous adverse reactions in children: proposal for paediatric‐focused clinical criteria

Abstract

Severe cutaneous adverse reactions (SCARs) are challenging to diagnose and manage in children for two main reasons: 1) The literature on SCARs in children is sparse and extrapolated from adult data, 2) Many paediatric blistering SCAR cases are qualified as atypical or incomplete erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) because certain clinical features make them not fit into this adult classification. Our panel proposes paediatric-focused clinical criteria for blistering SCARs in children to improve early diagnosis and facilitate acute management.