Illness representations and psychological outcomes in chronic lymphocytic leukaemia.

Abstract

OBJECTIVES\nChronic lymphocytic leukaemia (CLL) is a lifelong cancer with subtle symptoms. Treatment is not curative and often involves repeated relapses and retreatments. Illness perceptions - cognitive and emotional representations of illness stimuli - were studied in CLL patients to: 1) identify illness perception profiles prior to treatment; and 2) test whether profile membership predicts psychological responses 12\xa0months later as treatment continued.\n\n\nDESIGN\nCLL patients (N\xa0=\xa0259), randomized to one of four cancer treatment trials testing targeted therapy, were assessed before starting treatment and at 12\xa0months.\n\n\nMETHODS\nThe Brief Illness Perception Questionnaire (BIPQ) assessed perceived consequences, timeline, personal/treatment control, identity, comprehension, concern, and emotions toward CLL. Psychological outcomes were depressive symptoms (PHQ-9/BDI-II), negative mood (POMS), and cancer stress (IES-R). Latent profile analysis (LPA) determined number of profiles and differential BIPQ items for each profile. Multilevel models tested profiles as predictors of 12-month psychological outcomes.\n\n\nRESULTS\nLPA selected the three-profile model, with profiles revealing Low (n\xa0=\xa0150; 57.9%), Moderate (n\xa0=\xa021; 8.1%), and High-impact (n\xa0=\xa088; 34.0%) illness representations. Profiles were defined by differences in consequences, identity, concern, and emotions. Profile membership predicted all psychological outcomes (ps<.038). Low-impact profile patients endorsed minimal psychological symptoms; High-impact profile patients reported substantial symptoms.\n\n\nCONCLUSIONS\nResults of the first CLL illness representation study provide directions for future clinical efforts. By identifying differences among patients perceptions of CLL consequences, symptom burden, concerns, and emotional responses, an at-risk patient group might receive tailored psychological treatment. Treatments may address negative perceptions, to reduce psychological risk associated with chronic cancer.