British Journal of Pharmacology | 2021
Identification of WP1066, an inhibitor of JAK2 and STAT3, as a KV1.3 potassium channel blocker
Abstract
KV1.3 potassium channels play a predominant role in regulating calcium signalling that is essential for the activation and proliferation of effector memory T (TEM) cells. This ion channel has been recognized as a promising therapeutic target against various autoimmune diseases.