British Journal of Pharmacology | 2021
Scorpion venom heat‐resistant synthesized peptide ameliorates 6‐OHDA‐induced neurotoxicity and neuroinflammation: likely role of Nav1.6 inhibition in microglia
Abstract
Microglia‐related inflammation is associated with the pathology of Parkinson s disease. Functional voltage‐gated sodium channels (VGSCs) are involved in regulating microglial function. Here, we aim to investigate the effects of scorpion venom heat‐resistant synthesized peptide (SVHRSP) on 6‐hydroxydopamine (6‐OHDA)‐induced Parkinson s disease‐like mouse model and reveal its underlying mechanism.