Three‐dimensional nail imaging by optical coherence tomography: a novel biomarker of response to therapy for nail disease in psoriasis and psoriatic arthritis

Abstract

of local heat therapy in treating chromoblastomycosis may not only depend on its direct impact on the fungus. Enhancement of local immunity against the fungal infection, as proposed by Takahashi et al., probably plays an important role. Additionally, increasing the temperature of the local environment may cause denaturation of skin proteins such as keratin and collagen, which may impede adherence of the fungus to epithelial tissue and prevent its further growth. Local heat therapy for treating chromoblastomycosis has been reported for over 30 years, but this remedy is frequently ignored in clinical practice nowadays, possibly due to a lack of standard methodology. However, we believe heat therapy at 40 °C for 8 h/day to be an effective and tolerable therapeutic option for patients with cutaneous chromoblastomycosis. We hope this traditional remedy with few AEs may find its way back to the clinical practice again.