Primary aldosteronism is associated with decreased low‐density and high‐density lipoprotein particle concentrations and increased GlycA, a pro‐inflammatory glycoprotein biomarker

Abstract

Primary aldosteronism (PA) may confer increased cardiovascular risk beyond effects on systemic blood pressure, but contributing mechanisms remain incompletely understood. We compared plasma (apo)lipoproteins and lipoprotein particle characteristics, GlycA, a pro‐inflammatory glycoprotein biomarker of enhanced chronic inflammation, and plasma total branched‐chain amino acids (BCAA), measured using nuclear magnetic resonance (NMR) spectroscopy, between patients with PA, control subjects without hypertension, subjects with untreated hypertension and subjects with treated hypertension.