Partial depletion and repopulation of microglia have different effects in the acute MPTP mouse model of Parkinson’s disease

Abstract

Parkinson s disease (PD) is a common neurodegenerative disorder characterized by the progressive and selective degeneration of dopaminergic neurons. Microglial activation and neuroinflammation are associated with the pathogenesis of PD. However, the relationship between microglial activation and PD pathology remains to be explored.