The development of multiple ocular complications in a patient with Parry‐Romberg syndrome

Abstract

Parry-Romberg syndrome (PRS) is a rare condition that causes progressive but selflimited atrophy of facial tissues, muscles, and osteocartilaginous and cerebral structures. PRS can present with a variety of periocular, ocular, neurological and systemic manifestations. While the exact cause of PRS is unknown, it is thought to be due to an inflammatory process or dysfunction of the cerebral sympathetic nervous system. PRS typically affects one side of the body, with characteristic hemifacial atrophy. Periocular and ocular involvement occurs in 10–35 per cent of patients with PRS, and may occur long after the stabilisation of facial changes. The age of onset of PRS is usually within the first two decades of life with females affected more than males by a ratio of three to two. Progression of the disease can vary between two and 20 years, followed by stabilisation. In 45 per cent of patients with PRS, neurological complications such as trigeminal neuralgia, migraine or seizures accompany the condition. This case report details the development of multiple ocular complications in one patient with PRS. Case report