Occult primary white matter impairment in Leber hereditary optic neuropathy

Abstract

Leber hereditary optic neuropathy (LHON) is a disease maternally inherited from mitochondria that predominantly impairs the retinal ganglion cells and their axons. To identify whether occult brain white matter (WM) impairment is involved, a voxel‐based analysis (VBA) of diffusion metrics was carried out in LHON patients with normal‐appearing brain parenchyma.